Loads of people are interested in weight loss injections like Mounjaro right now. And while mostly, the focus is on the results they can drive—on Mounjaro, you might lose around 25% of your starting weight—there have been some questions about side effects, too.
For one, does Mounjaro cause pancreatitis? It’s rare, but the condition does develop in some people. But how do you know if you have it? Here’s the lowdown.
Does Mounjaro cause pancreatitis?
Again, it’s rare, but pancreatitis (when your pancreas is inflamed) has been reported in some people taking Mounjaro. It’s estimated that this affects up to 1% of people on the medicine.
An analysis of different studies found that overall, 0.32-0.39% of people taking different doses of Mounjaro (either 5mg, 10mg, or 15mg) developed pancreatitis.
Pancreatitis symptoms
The main thing to look out for is a severe pain in your stomach that usually gets worse and can sometimes travel to your back. Eating or drinking may make you feel worse very quickly, especially if you eat fatty foods. Leaning forward or curling into a ball may help to relieve the pain, but lying flat on your back often makes it worse.
There are other symptoms that should be on your radar, too:
- Vomiting or nausea
- Indigestion
- A fever (a temperature of 38C or more)
- A tender or swollen stomach
- Your skin and the whites of your eyes becoming more yellow in colour (jaundice)
- Rapid breathing or your heart beating faster
Can I prevent pancreatitis while on Mounjaro?
There’s no way to predict which side effects you’ll get while using Mounjaro, unfortunately. Nor is there any way to guarantee that you won’t get pancreatitis, though the chances of it happening are low. However, there are steps you can take to reduce your risk.
Drink less alcohol
Drinking too much is one of the main causes of pancreatitis. There’s even a name for it: alcoholic pancreatitis. So, cutting back on alcohol can lower your risk.
Though if you’ve already had pancreatitis that was caused by alcohol, you should stop altogether. We recommend avoiding alcohol while using Mounjaro anyway—it can work against your health goals and bring on unwanted effects.
Eat well
The other most common cause of pancreatitis is gallstones, which are small stones that form in your gallbladder. Eating a nutritious, balanced diet can help prevent them from developing.
Here, the advice is to:
- Eat foods high in fibre, including fruits and vegetables, and whole grain foods.
- Because there seems to be a link between having high cholesterol and developing gallstones, you should opt for healthier fats (unsaturated fats, like olive oil) instead of saturated fats like butter or coconut oil.
- Eat fewer foods with refined carbohydrates, such as white bread and pasta.
- Steer clear of foods with added sugars, like cakes and fizzy drinks. Natural sugars in fruit and veg are absolutely fine though—so don’t fear the fruit bowl!
Our team of coaches can help you put together a diet plan that works for you as part of our weight loss programme.
Side effects support at Voy
"If you're using Voy and you experience any side effects, rest assured that our expert clinicians are just a message or phone call away. They can adjust your dose, prescribe medication to ease your symptoms, or simply offer reassurance.
Everyone responds differently to weight loss treatment and we'll help you find what feels right for you."
Reach a healthy weight
Getting to a healthy weight might also help to prevent gallstones.
As well as following a healthy diet that supports weight loss, it’s recommended that you move your body regularly. Try to do 150 minutes of moderate-intensity movement and two strength sessions per week. Weight loss medication can help here, too.
Follow your provider’s advice
When you start taking Mounjaro, your provider will tell you to take the lowest strength first so that your body can adjust to the medicine. Then, if you’re tolerating it okay, you’ll gradually increase your dose every four weeks. This can reduce your risk of getting side effects.
When to see your doctor
If you think you might have pancreatitis, you should see your doctor right away. Pancreatitis needs to be treated in a hospital, though most people will start to feel better within a week.
So, if you experience any of the symptoms we mentioned earlier, get in touch with them asap.
You should stop taking Mounjaro if you have pancreatitis. Your provider will confirm this and tell you what you should do next, so make sure you follow their instructions exactly.
Your weight loss journey
We get that it might feel a little overwhelming to learn about the serious side effects of a medicine. But it’s so important to know what signs to look out for, even if the chances of you getting pancreatitis are slim.
Remember: you will only be prescribed Mounjaro injections if the benefits outweigh the risks for you personally. Reaching a healthy weight can reduce your risk of type 2 diabetes and heart disease, give you more energy, help you sleep better, and more.
Through our weight loss programme, you’ll get one-to-one support from our team of clinicians and coaches. They’ll check in with you on the regular, and help you keep tabs on any symptoms you’re experiencing so you can get any help you need asap.
Find out if you’re eligible for the programme by taking this short quiz.
FAQs
Is pancreatitis a common side effect of Mounjaro?
Nope—it’s estimated to affect up to 1% of people on the medicine. But it’s certainly something that should be on your radar. Pancreatitis needs to be seen to in a hospital and if left untreated, it can bring on other complications. So if you think you might have it, get yourself checked.
What should I do if I experience symptoms of pancreatitis while taking Mounjaro?
You should get in touch with your provider right away. While most people taking Mounjaro won’t get pancreatitis, it’s considered a serious side effect and needs to be treated. The main symptom to look out for is a severe pain in your stomach that doesn’t go away and can travel to your back.
¹Aronne, Louis J, et al. “Continued Treatment With Tirzepatide For Maintenance of Weight Reduction in Adults with Obesity: the SURMOUNT-4 Randomised Clinical Trial.” JAMA
, vol. 331, no. 1, 2024:38-48. https://jamanetwork.com/journals/jama/fullarticle/2812936.
²“Can What I Eat Help Prevent Gallstones?” NIH, www.niddk.nih.gov/health-information/digestive-diseases/gallstones/eating-diet-nutrition Accessed 11 Mar. 2025.
³“EASL Clinical Practice Guidelines on the Prevention, Diagnosis and Treatment of Gallstones,” Journal of Hepatology, vol. 65, issue 1, 2016:146-181 https://www.journal-of-hepatology.eu/article/S0168-8278(16)30032-0/fulltext.
⁴Kamrul-Hasan, A B M, et al. “Pancreatic Safety of Tirzepatide and its Effects on Islet Cell Function: a Systematic Review and Meta-analysis.” Obesity Science & Practice, vol. 10, issue 6, 2024:e70032. pmc.ncbi.nlm.nih.gov/articles/PMC11667760/.
⁵Klochkov, Anton, et al. “Alcoholic Pancreatitis,” in StatPearls, Treasure Island (FL): StatPearls Publishing, 2023. www.ncbi.nlm.nih.gov/books/NBK537191/. Accessed 11 Mar. 2025.
⁶Mishre, Rahul, et al. “Adverse Events Related to Tirzepatide.” Journal of the Endocrine Society, vol. 7, issue 4, 2023:bvad016. pmc.ncbi.nlm.nih.gov/articles/PMC9915969.
⁷“Mounjaro: Information for the Patient.” Electronic Medicines Compendium. https://www.medicines.org.uk/emc/files/pil.15481.pdf Accessed 11 Mar. 2025.
⁸“Mounjaro: Full Prescribing Information.” Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215866s000lbl.pdf Accessed 11 Mar. 2025.
⁹“Symptoms: Acute Pancreatitis.” NHS. www.nhs.uk/conditions/acute-pancreatitis/symptoms/ Accessed 11 Mar. 2025.
¹⁰“Treatment: Acute Pancreatitis.” NHS. www.nhs.uk/conditions/acute-pancreatitis/treatment/ Accessed 11 Mar. 2025.
